Possible Interaction: Hydrocortisone and Progesterone

“In …, progesterone significantly increased the secretion of cortisol compared with estradiol [area under the curve (t(74) = 3.1; P < 0.01)] and urinary free cortisol (t(74) = 3.2; P < 0.01) and ACTH compared with hypogonadism [area under the curve (t(74) = 2.4; P < 0.05)].”

“A positive correlation between cortisol and progesterone was found before and after surgery.”

“ Hydrocortisone and dexamethasone highly augment the cAMP-stimulated progesterone production, whereas testosterone and PRL enhanced cAMP-induced progesterone synthesis only moderately.”

“An excess of progesterone inhibited the transepithelial transport of cortisol by P-glycoprotein.”

“In the non-salt-losing form of the adrenogenital syndrome of congenital adrenal hyperplasia without treatment, failure of feedback inhibition by Cortisol may result in overproduction of adrenocorticotropic hormone (ACTH) which, in turn, may lead to overproduction of progesterone.”

“These findings suggest that cortisol and progesterone play different roles in the attunement of stress and subsequent affiliation.”

“As cortisol regulation is a delicate process, we review some of the basic mechanisms by which progesterone , its potent metabolites, and estradiol regulate cortisol output and circulation to contribute to the net effect of higher cortisol in the follicular phase.”

“Contrary to expectations, progesterone is shown to impact the distribution of cortisol in plasma both under circumstances with high levels as seen in pregnancy and during the normal menstrual cycle of women.”

“However, physiological concentrations of testosterone and hydrocortisone inhibited CatSper activation by progesterone.”

“Interestingly, both testosterone and hydrocortisone antagonize the action of progesterone at physiological concentrations, which may explain why elevated levels of these steroids in the female organism affect fertility.”

“CONTEXT Plasma corticosteroid-binding globulin (CBG) transports cortisol but high progesterone levels at the maternal-fetal interface can displace cortisol from its steroid-binding site.”