Possible Interaction: Hydrocortisone and Potassium

“As a result the receptor is exposed to cortisol or corticosterone in high concentration which results in sodium retention and potassium loss.”

“These results suggest a permissive role of cortisol on glomerulosa response to potassium.”

“Cortisol and corticosterone but not aldosterone were produced by the decapsulated cell preparation, ACTH (α 1-24) but not angiotensin II or potassium significantly increased cortisol production by these cells.”

“The administration of large amounts of potassium appears to be ineffective in altering adrenal secretion of aldosterone or of hydrocortisone.”

“Additionally, in a cell line expressing both the glucocorticoid intracellular receptor and recombinant, fast inactivating potassium channels (hKv1.3), cortisol (1 and 10 μM) inhibited potassium currents by shifting their steady‐state activation curves to the right by 12 mV (10 μM cortisol).”

“ Cortisol (10 μM) inhibited whole‐cell potassium currents in parvocellular neurones by shifting the steady‐state activation curve by 14 mV to the right.”

“Plasma potassium levels significantly increased in testosterone plus cortisol treated males.”

“The addition of cortisol (1 microgram/ml) to cells slightly reduced passive potassium uptake, but not to the same extent as did 10(-8) M ACTH.”