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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydrocortisone
supplement:
Polypeptides
Research Papers that Mention the Interaction
“ Cortisol also decreased FGF-2 and PDGF BB-induced HGF/SF mRNA and polypeptide levels in MC3T3 cells.”
Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts.“The effect was maximal after 48 h of treatment and observed with cortisol concentrations of 10 nM to 1 microM. Treatment with cortisol also increased IGFBP-6 polypeptide levels in the medium, as determined by Western immunoblot analysis.”
“ Cortisol decreased IGFBP-5 polypeptide levels in the extracellular matrix and caused a time- and dose-dependent decrease in IGFBP-5 mRNA.”
“Altered synthesis of keratin polypeptides follows inhibition of scale morphogenesis by hydrocortisone and TAC.”
“In contrast, prolonged exposure to 14 microM HC for 14-21 days decreased MuMTV polypeptide synthesis, surface antigen expression, and virion production to levels similar to untreated MJY-alpha cells.”
“ Hydrocortisone inhibits prostaglandin generation by rat peritoneal leucocytes by releasing the polypeptide phospholipase inhibitor, macrocortin.”
“We suggest that cortisol has no effect on basal prostaglandin production but blocks the synthesis or release occurring in response to polypeptide hormone stimulation.”
“When the liver was perfused with hydrocortisone plus the polypeptide , the increase in the enzyme activities was amplified 4- to 5-fold, while the inclusion of the polypeptide alone in the perfusion fluid resulted in no changes in the enzyme activity.”
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