Possible Interaction: Hydrocortisone and Oxytocin

“Our results demonstrated an inhibitory effect of exogenous oxytocin on ACTH and cortisol release.”

“The findings suggest that the interplay between oxytocin and cortisol is dynamic and sensitive to the anticipation of stress or novelty.”

“There may be dynamic interactions between the two neurohormones, with greater activation under cortisol , facilitating stronger positive feelings under oxytocin.”

“Breastfeeding-induced oxytocin release was associated with elevated prolactin levels; lowered ACTH and cortisol (stress hormones) and somatostatin (a gastrointestinal hormone) levels; enhanced sociability; and reduced anxiety, suggesting that oxytocin induces physiological and psychological adaptations in the mother.”

“Baseline cortisol and baseline oxytocin were significantly correlated in both sessions.”

“Previous research suggests a dynamic regulatory relationship between oxytocin and cortisol , but the specific nature of this relationship and its context-specificity have not been fully specified.”

“These findings contribute new insights regarding associations between cortisol and oxytocin reactivity and recovery in different psychological contexts.”

“Furthermore, oxytocin ’s effect was moderated by baseline cortisol level, such that oxytocin mitigated cortisol reactivity to a greater extent among participants with higher, as compared with lower, baseline cortisol.”

“Single dose of OT decreased the level of cortisol and improved the cortisol/DHEAS ratio in the heroin users during abstinence (p < 0.01).”

“ OXT and CORT increase as well as OXT increase and CORT recovery were positively correlated.”

“ OXT and cortisol appear to be co‐activated in response to stress.”

“Together, the results suggest that cortisol and oxytocin might be associated with opposite effects on CM-related alterations in the bioenergetic profile of peripheral immune cells.”

“Although cortisol increases and oxytocin rapidly declines upon awakening, their diurnal variation does not appear to be related at basal, peripheral levels, consistent with a previous finding that exogenously administered oxytocin only modulates cortisol under conditions of stress.”