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Last Updated: 2 years ago

Possible Interaction: Hydrocortisone and Leucine

supplement:

Leucine

Research Papers that Mention the Interaction

Salivary free cortisol is a non-invasive and practical alternative; however, when cortisol concentrations exceed 500 nmol · L there is a lack of agreement between salivary (free) and venous (bound) cortisol.
International journal of sports medicine  •  2012  |  View Paper
Hydrocortisone treatment also resulted in increased incorporation of leucine into protein and decreased breakdown of pre-labeled protein in both confluent and logarithmically growing cultures.
Mechanisms of Ageing and Development  •  1981  |  View Paper
Hydrocortisone supplementation resulted in enhanced [3H]leucine uptake by the cells, inhibited in the presence of anti-rat albumin serum.
General pharmacology  •  1986  |  View Paper
In non mitogen stimulated thymocytes, cortisol (10−6 M) inhibits leucine incorporation into protein by 30%, whereas in Con A stimulated cells, cortisol inhibits leucine incorporation by 50%.
The inhibitory effect of cortisol on leucine incorporation is dose and time dependent in both control and Con A treated cells.
Journal of steroid biochemistry  •  1979  |  View Paper
Cortisol inhibited the rate of [3H]leucine incorporation into protein during the initial 4h of incubation, but it had no effect at subsequent times.
The Biochemical journal  •  1976  |  View Paper
In intact sensitive cells, free fatty acid (FFA) decreased the uptake of thymidine but did not mimic the other inhibitory effects of cortisol on uptake of deoxyglucose, leucine , or uridine.
Cancer research  •  1974  |  View Paper
Hydrocortisone stimulated the catabolism of prelabeled fatty acyls in mouse L fibroblasts supplemented with exogenous fatty acid.
The Journal of biological chemistry  •  1978  |  View Paper
Cortisol in vitro, at concentrations down to 10−7M, significantly decreases net glucose uptake by such cell preparations during the first hour of incubation, and at 10−6M (the only concentration tested) decreases the incorporation of leucine into protein during the second hour.
Biochimica et biophysica acta  •  1964  |  View Paper
Hydrocortisone inhibited the incorporation of glycine, leucine , phenylalanine and valine; incorporation of either methionine or serine was not affected.
Endocrinology  •  1963  |  View Paper