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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Hydrocortisone and Daidzein

supplement:

Daidzein

Research Papers that Mention the Interaction

In cultured human fetal and postnatal adrenal cortical cells, genistein and daidzein (both 0.4-40 micromol/L) decreased ACTH-stimulated cortisol production to basal levels (ED50, 1-4 micromol/L).
The Journal of clinical endocrinology and metabolism  •  1999  |  View Paper
Genistein and daidzein inhibited basal and ACTH-stimulated secretion of cortisol and corticosterone and stimulated secretion of androstenedione.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2014  |  View Paper
We demonstrated that in sexually mature, cyclic pigs, regardless of the phase of the estrous cycle, phytoestrogens genistein and daidzein suppressed basal and ACTH-stimulated in vitro secretion of cortisol and corticosterone via progesterone synthesis inhibition.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2013  |  View Paper
Genistein, daidzein and biochanin A suppressed cortisol output, whereas androstenedione secretion was enhanced by these phytoestrogens.
Acta veterinaria Hungarica  •  2007  |  View Paper