Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Hydrocortisone and Ascorbate

supplement:

Ascorbate

Research Papers that Mention the Interaction

A negative correlation between serum levels of cortisol and ascorbate (r = –0.30, p < 0.05) was also observed.
Annals of Nutrition and Metabolism  •  2008  |  View Paper
Hydrocortisone (1.5 μM) blocked the ascorbate‐related increase in collagen production during growth and in confluent cultures.
Inhibition of collagen production by hydrocortisone was observed only in the presence of ascorbate , while the increase in growth and noncollagen protein production occurred in the presence and absence of the vitamin.
Journal of cellular physiology  •  1981  |  View Paper
Only cortisol produced a consistent stimulation of the cells; the response was dose-related over the range 0.01 to 1.0 mumol/l and was greatly enhanced in the presence of ascorbate.
Journal of reproduction and fertility  •  1988  |  View Paper
The same range of ascorbate concentrations added to cells during a 24-h preincubation with cortisol showed increasing prevention of loss of 11 beta-hydroxylase activity.
When primary bovine adrenocortical cells were cultured in a serum-free defined medium in the absence of ACTH, 11 beta-hydroxylase activity declined with … for 11 beta-hydroxylase, was added to such cultures, 11 beta-hydroxylase activity declined with a half-time of about 6 h. Ascorbate (5 … cortisol.
Endocrinology  •  1985  |  View Paper