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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Hydrocortisone
supplement:
Ascorbate
Research Papers that Mention the Interaction
“A negative correlation between serum levels of cortisol and ascorbate (r = –0.30, p < 0.05) was also observed.”
Serum Homocysteine: Relationship with Circulating Levels of Cortisol and Ascorbate“ Hydrocortisone (1.5 μM) blocked the ascorbate‐related increase in collagen production during growth and in confluent cultures.”
“Inhibition of collagen production by hydrocortisone was observed only in the presence of ascorbate , while the increase in growth and noncollagen protein production occurred in the presence and absence of the vitamin.”
“Only cortisol produced a consistent stimulation of the cells; the response was dose-related over the range 0.01 to 1.0 mumol/l and was greatly enhanced in the presence of ascorbate.”
Enhanced secretion of oxytocin from bovine granulosa cells treated with adrenal steroids.“The same range of ascorbate concentrations added to cells during a 24-h preincubation with cortisol showed increasing prevention of loss of 11 beta-hydroxylase activity.”
“When primary bovine adrenocortical cells were cultured in a serum-free defined medium in the absence of ACTH, 11 beta-hydroxylase activity declined with … for 11 beta-hydroxylase, was added to such cultures, 11 beta-hydroxylase activity declined with a half-time of about 6 h. Ascorbate (5 … cortisol.”
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