Possible Interaction: Hydrochlorothiazide and Potassium

“Plasma sodium was increased by 2% only by furosemide, whereas potassium was decreased by 15 and 19% by hydrochlorothiazide and chlorthalidone, respectively, but not by furosemide.”

“Nicardipine caused no significant changes in blood chemistry, whereas HCTZ caused statistically significant decreases (P < 0.001) in sodium and potassium and increases (P < or = 0.01) in glucose, BUN, creatinine, uric acid, cholesterol and LDL compared with baseline.”

“ Hydrochlorothiazide treatment caused potassium loss and an increase in the levels of uric acid and triglycerides.”

“ HCTZ significantly decreased potassium levels at rest and during exercise by 0.2 mmol l-1.”

“In the study reported here dosages as high as 60 to 80 mmol/day of orally administered potassium failed to prevent hypokalemia in 7 of 19 hypertensive patients who were receiving hydrochlorothiazide.”

“Mean potassium concentrations decreased by 0.39 mmol/l with bendroflumethiazide/potassium chloride and by 0.30 mmol/l with hydrochlorothiazide/amiloride.”

“RESULTS Hy rochlorothiazide si gnificantly decreased urine calcium and pot assium co ncentration and excretion.”

“The administration of hydrochlorothiazide , albeit associated with captopril, could have decompensated the potassium balance, thus precipitating the acute rhabdomyolysis.”

“Diuretic treatment hydrochlorothiazide ) induced a marked decrease of red cell membrane Na+K+ ATPase activity in excessive potassium loser hypertensive patients.”

“During the hydrochlorothiazide treatment, potassium and magnesium levels decreased significantly (p less than 0.001).”