Possible Interaction: Hydrochlorothiazide and Calcium Supplement

“Serum potassium, serum chloride, urinary osmolality, and urinary calcium decreased after treatment with hydrochlorothiazide.”

“ HTZ administration was also accompanied by less negative Ca balances, averaging +1.6 +/- 1.0 mmoles/day; P less than 0.025, and by a fall in daily urinary hydroxyproline excretion averaging -0.13 +/- 0.09 mmoles/day; P less than 0.025.”

“ResultsWe demonstrated that serum calcium Ca ) increased in ten patients (52.6%) after HCTZ use, returning to previous levels after the washout period.”

“Neither CTL nor HCTZ at 12.5 mg QD significantly lowered UCa.”

“We hypothesize that HCTZ is associated with less reduction in UCa than is CTL when comparing currently used doses.”

“CONCLUSION HC Z do ses greater than 0.4 mg/kg/d decreased cal cium ex cretion, but were associated with significant adverse events.”

“ HCTZ raised serum levels of calcium (Ca) in 1oHPT (P<0.001) and PHP type I (P<0.01) but did not increase urinary excretion of Ca.”

“Addition of hydrochlorothiazide (1 mg/kg) reduced their urinary calcium excretion and maintained their serum calcium concentrations near the lower limit of normal, allowing the 1,25-dihydroxyvitamin D(3) and 1alpha-hydroxyvitamin D(3) doses to be reduced, and it alleviated their symptoms.”

“In affected subjects, HCTZ reduced mean serum K(+) by 1.12 mmol/liter, mean serum Cl(-) by 6.2 mmol/liter, and mean urinary calcium by 65% and elevated mean serum calcium by 0.11 mmol/liter and mean serum urate by 118 micromol/liter.”

“ HCTZ (100 μM) also stimulated calcium (Ca2+) uptake (8.26 ± 1.78 pmol/mg protein/15 minutes vs. 13.6 ± 0.49 pmol/mg protein/15 minutes; p < 0.05) in MG‐63 cells.”

“A single 50 mg dose of hydrochlorothiazide (HCTZ) decreases the urinary excretion of calcium (U(Ca)V), clearance (C(Ca)) and fractional excretion (FE(Ca)) of calcium.”