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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydralazine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“ Ascorbic acid increased the response of prolyl hydroxylase to hydralazine from 1.5- to 2-fold to 3- to 7-fold, whereas it decreased the response of lysyl hydroxylase to hydralazine from 4- to 8-fold to 2- to 3-fold.”
“In both normal and mutant cells the relative magnitude of the hydralazine effect could be modified by ascorbic acid in the culture medium.”
A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts.
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