Possible Interaction: Hydralazine and Calcium Supplement

“This characteristic distinguishes them from other drugs such as sodium nitroprusside, papaverine, hydralazine and diazoxide which interfere with the availability of calcium ions for their physiological functions by acting at sites other than the 'calcium channels'.”

“This characteristic distinguishes them from other drugs such as sodium nitroprusside, papaverine, hydralazine and diazoxide which interfere with the availability of calcium ions for their physiological functions by acting at sites other than the ‘calcium channels’.”

“It is concluded that human arteries are much more sensitive to the effects of hydralazine than are human veins and that the mechanism of action of hydralazine is probably due to inhibition of the release of tightly bound calcium ions.”

“Our results also suggest that the inhibition by hydralazine of the contractions elicited by Ca2+ (in Ca(2+)-free depolarizing high-K+ 55 mM solution) and by methoxamine is not due to an action on voltage-dependent Ca2+ channels, but may reflect an intracellular site of action.”

“Thus, the direct vasodilator action of hydralazine may be related to its interference with the movement and/or translocation of calcium across the cell membrane.”

“Captopril, hydralazine , and verapamil may have a common ability to reduce intracellular calcium and therefore inhibit DNA synthesis.”

“The results suggest that hydralazine , at least at high concentrations, may interfere with the transmembrane movements of calcium ions in vascular smooth muscle.”

“ Apressin was found to raise the negative electricity of the biopotential and the potassium level in the vascular tissue, an increase of the dose producing not any further reduction, but rather a higher concentration of calcium in the arterial vessels.”

“Both the threshold and the maximum tension responses of strips to Ca++ (K+-depolarized tissues) were altered by hydralazine in a dose-dependent manner.”

“ Hydralazine also raised the threshold to the inhibitory (relaxant) effects of higher (greater than 2.5 mM) bath concentrations of Ca++.”

“It is suggested that hydralazine inhibits K+ contractures in aortic strips by interference with the entry of Ca++ into the cell, reflecting an effect of hydralazine at the cell surface membrane.”

“The Ca++ uptake associated with K+ depolarization was inhibited by relaxant doses of hydralazine ; however, hydralazine did not significantly affect the rate of 45Ca++ efflux.”