Possible Interaction: Hyaluronoglucosaminidase and Adrenocorticotropic Hormone

“The concept that adrenal steroids promote hyaluronidase activity stands in contrast to the impressive array of data compiled by other investigators which demonstrate that …, 1950; Seifter, Baeder and Begany, 1949), cortisone (Winter and Flataker, 1950; Seifter et al., 1950; Seifter, Baeder and Dervinis, 1949; Opsahl, 1949a) and ACTH (… hyaluronidase.”

“Summary Anti-hyaluronidase agents , i.e. phosphorylated hesperidin, d-alphatocopherol phosphate, and chrondroitin sulfate were shown to be capable of increasing the effectiveness of administered pituitary trophic hormones such as follicle stimulating hormone (FSH) and corticotrophin.”

“Coincidental anti-proteolytic action of these substances further enhanced such activity when the anti-hyaluronidase material together with the corticotrophin was injecte...”

“Recently (Cohen, et al., 1953) data were presented by the authors which demonstrated that anti-hyaluronidase agents are effective in delaying the absorption and in enhancing the activity of adrenocorticotrophin.”

“ ACTH given parenterally exhibited a significant antihyaluronidase effect.”

“4) In lymphocytic leukemia and Hodgkin's disease, cortisone, ACTH and other forms of therapy cause a decrease in the anti-hyaluronidase titre corresponding with clinical improvement. (”

“Summary ACTH brings out a marked decrease in the level of the “nonspecific” hyaluronidase inhibitor in patients with rheumatic fever.”