Possible Interaction: Homocysteine and Vitamin B 12

“OBJECTIVES Vitamin B-12 and n-3 polyunsaturated fatty acids (PUFA) decrease blood homocysteine (Hcy) concentrations.”

“ Vitamin B-12 , fish oil, and vitamin B-12+fish oil supplementation lowered plasma Hcy concentrations by 22%, 19%, and 39%, respectively.”

“With supplementation of both folic acid and vitamin B12 , the levels of ADMA and Hcy decreased significantly at 2 and 12 weeks (p<0.05).”

“Plasma level of vitamin B12 in the lowest quartile significantly increased tHcy level in PAD patients, and it was independent of plasma folate level.”

“Daily supplementation with vitamin B12 and folate, which are the cofactors of the enzymatic reactions involved in Hcy metabolism, can lower plasma levels of Hcy , so it is recommended to take these vitamins in case of deficiency along with Iso to prevent premature occlusive vascular disease.”

“Hyperhomocysteinemia may be an early indicator for vitamin B12 disorders because cobalamin is a cofactor in the remethylation process of homocysteine.”

“One therapeutic approach for tHcy reduction is vitamine supplementation, since folic acid and cobalamine catalyse and enhance metabolism of tHcy to methionine.”

“These results … intravenous cyanocobalamin at 7- or … intervals reduces plasma tHcy concentrations of hemodialysis patients below the levels brought about by prior long-term administration every 4 weeks and confirms … tHcy lowering with parenteral cobalamin is a true pharmacological effect and not merely correction of a latent deficiency state.”

“We and others have reported that cobalamin , administered parenterally, reduces plasma tHcy substantially below the lowest concentrations attainable with folic acid.”

“These results confirm that weekly cobalamin injections lower plasma tHcy concentrations of hemodialysis patients well below the level attainable with folic acid.”

“In the treated group, significant negative correlations were observed between homocysteine and folate values (r=-0.586, p=0.017) and between homocysteine and Vitamin B12 values (r=-0.672, p=0.004).”

“An initial 6-week period of vitamin supplementation (1.0 mg folic acid, 10 mg pyridoxine, 0.05 mg cyanocobalamin ) reduced plasma homocysteine levels 54.7% (P<0.001).”