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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Vasodilator Agents
Research Papers that Mention the Interaction
“In vitro, homocysteine can inhibit the thromboresistance properties of the endothelial cell by induction of procoagulant factors, inactivation of natural anticoagulant systems, and suppression of vasodilatory and platelet-modulating factors.”
Inhibition of endothelial cell thromboresistance by homocysteine.“Conclusions We showed that a pathophysiological concentration of homocysteine increases the spontaneous arteriolar constriction and inhibits the 17&bgr;-estradiol-induced, endothelium-mediated, rapid vasodilatory effect on muscle arterioles from the female rat.”
Homocysteine impairs estrogen-induced vasodilation in isolated rat arterioles“While homocysteine infusion produced no change in the mean femoral arterial blood pressure, each of these vasodilators led to a rapid and substantial dose-dependent fall in blood pressure.”
“The respect, one of the common causes of deregulation in endothelial vasodilator function have been associated with down-regulation of the NO synthesis and an increase in plasma levels of asymmetric dimethylarginine (ADMA) and homocysteine.”
Plasmatic Concentrations of ADMA and Homocystein in Llama (Lama glama) and Regulation of Arginase Type II: An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia“ Homocysteine inhibited vasorelaxant response to the BKCachannel opener NS1619, lowered BKCa β1 subunit protein level and suppressed BKCa current.”
“ Homocysteine inhibited vasorelaxant response to the BKCa channel opener NS1619, lowered BKCa β1 subunit protein level and suppressed BKCa current.”
“The normal vasodilator properties of endothelium are inhibited by Hcy , and this inhibition is subject to modulation by nitric oxide.”
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