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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Tolbutamide
Research Papers that Mention the Interaction
“ Homocysteine also dose-dependently inhibited insulinotropic responses to a range of glucose-dependent secretagogues including nutrients (alanine, arginine, 2-ketoisocaproate), hormones (glucagon-like peptide-1 (7-36)amide, gastric inhibitory polypeptide and cholecystokinin-8), neurotransmitter (carbachol), drug ( tolbutamide ) as well as a depolarising concentration of KCl or elevated Ca2+.”
Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.“Insulinotropic responses to alanine, arginine, 2-ketoisocaproate, elevated Ca2+, tolbutamide , potassium chloride (KCl), forskolin, and phorbol 12-myristate 13-acetate were also significantly reduced by homocysteine.”
Homocysteine-Induced Impairment of Insulin Secretion From Clonal Pancreatic BRIN-BD11 &bgr;-Cells Is Not Prevented by Catalase
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