Possible Interaction: Homocysteine and Taurine

“Supplementation with cysteine or taurine , however, was found to be effective in reducing plasma homocysteine levels.”

“ Taurine , an end metabolic product of homocysteine, obviously reduces cardiovascular injury induced by homocysteine.”

“Arginine and taurine may protect against cardiovascular diseases while homocysteine may be a risk factor for them.”

“On the contrary, omega-3 fatty acids and some nutraceuticals, such as N-acetyl cysteine, taurine , or S-adenosyl-methionine, reduce both Hcy serum concentration and cardiovascular risk.”

“After taurine supplementation, plasma taurine and Hcy concentration exhibited a significant negative correlation (p < 0.05).”

“In conclusion, taurine is an effective nutrient that antagonizes Hcy levels.”

“On the other hand, the concentration of plasma Hcy was significantly decreased from 8.5 +/- 1.2 micromol/L to 7.6 +/- 1.1 micromol/L after taurine supplementation (p < 0.05).”

“Whether taurine decreases homocysteine directly or via a reduction of methionine is unclear.”

“Taken together, our results suggest that Hcy triggered ER stress in cardiomyocytes, which was the crucial molecular mechanism mediating Hcy-induced cardiomyocyte apoptosis, and the adverse effect of Hcy could be prevented by taurine.”

“Although taurine may be a cardiovascular cytoprotective substance, we hypothesized that it may antagonize the effects of homocysteine on myocardial mitochondrial function.”

“ Taurine (0.5 to 10 mmol/L), conversely, prevented these actions induced by homocysteine.”

“To elucidate the mechanisms by which homocysteine induces atherosclerosis and taurine prevents it, we examined whether homocysteine and taurine affect the expression and secretion of extracellular superoxide dismutase (EC-SOD), a glycoprotein secreted from vascular smooth muscle cells (VSMCs) that protects the vascular wall from oxidative stress.”

“Dialysate levels of taurine were increased significantly in animals injected with homocysteate.”