Possible Interaction: Homocysteine and Serine

“ l-Serine acts by competitively inhibiting homocysteine uptake in the cells.”

“Competition studies revealed that the small neutral amino acids tyrosine, cysteine, glycine, serine , alanine, methionine, and leucine inhibited Hcy uptake in both cell types, but the inhibition was greater for tyrosine, serine, glycine, and alanine in HAECs.”

“Since the intracellular concentration of serine is significantly greater than that of homocysteine , the physiological significance of this phenomenon needs to be considered.”

“It is thought that the suppressive effect of folate on choline deficiency-induced hyperhomocysteinemia was due to increased metabolism of homocysteine via the MS pathway and that the suppressive effect of serine was due to increased metabolism of homocysteine via cystathionine formation.”

“Raising dietary total amino acid level by adding 3.61% branched-chain amino acids (BCAA)+4.… amino acids (AAA) to choline-deprived 10C+0.5% methionine+0.32% glycine+0.94% serine resulted in a … in plasma homocysteine concentration to a level lower than … level in rats fed 10C.”

“Inclusion of serine significantly lowered homocysteine export in the normal protein group, but the effect was more marked in the high protein group.”

“N5-Methyltetrahydrofolate (5-CH3-THF) (100 microM), L-serine (6 mM), and L-methionine (6 and 12 mM) attenuated the embryotoxicity of L-homocysteine (6 mM) in GD10 rat embryos.”

“Radioactivity from l -[35S]homocysteine also appeared in methionine but the level of homocysteine required for maximal activity was tenfold that of serine.”

“The stimulatory effect of homocysteine on CF synthesis is enhanced by added serine but is inhibited by added formate.”

“A methionine load together with betaine and with serine increased homocysteine by 10.4 ± 2.8 μmol/l (p < 0.001 relative to placebo) and by 12.1 ± 8.2 μmol/l (p < 0.001 relative to placebo), respectively.”