Possible Interaction: Homocysteine and Selenium

“ Selenium inhibited the apoptosis of endothelial cells induced by homocysteine , through downregulating of Caspase-3 activity and expression of Caspase-3 and Bax, and by stimulating Bcl-2 expression.”

“ Selenium reversed the impaired viability and migration of endothelial cells induced by homocysteine in a dose-dependent manner.”

“It was hypothesised that sufficient Se reduces the flux of HCys through the transsulphuration pathway by decreasing the expression of glutathione (GSH) synthesising enzymes.”

“ Se supplementation increased plasma HCys and lowered GSH significantly by reducing the expression of GSH biosynthesis enzymes.”

“Conclusions: Lower Se was observed during acute IS, being inversely associated with and predicting increased tHCY levels.”

“Subjects with hyperhomocysteinaemia (tHCY ≧15 µmol/l) showed lower Se levels during IS; Se accounted for 15.4% of tHCY variations (R = –0.393; p = 0.015) with unit change increasing tHCY by 8.25 units.”

“ Homocysteine was negatively predicted by Se , suggesting a possible beneficial effect of Se.”

“In conclusion, selenium should be considered as a potential factor to lower tHcy.”

“ Serum selenium was inversely associated with tHcy , explaining 5.8% of tHcy variance with respect to 2.2% accounted for by serum folate.”

“Examining such interactions may prove exceedingly important to understanding the influence of selenium on tHcy.”

“It is certainly possible, as the authors conclude, that tHcy might be influenced by selenium status in populations with very low selenium status, such as in some parts of China but not in situations where mild deficiency exists such as in New Zealand.”

“Furthermore, Se inhibited the increased proliferation of CFs following HCY treatment.”