Possible Interaction: Homocysteine and S-Adenosylmethionine

“The blood concentrations of SAH paralleled those of tHcy, while the concentrations of SAM showed a bimodal relationship with those of tHcy.”

“Elevated levels of homocysteine also decrease the bioavailability of nitric oxide and modulate the levels of other metabolites including S-adenosyl methionine and S-adenosyl homocysteine which may result in cardiovascular diseases.”

“Evidence is reviewed which suggests that there is an analogy between the two systems and that S‐adenosyl methionine may catalyze a rearrangement of homocysteine on methionine synthase giving rise to iso‐ or beta‐methionine.”

“Elevated levels of homocysteine also decreases the bioavailability of nitric oxide and modulates the levels of other metabolites including S-adenosyl methionine and S-adenosyl homocysteine which may result in cardiovascular or neurological disorders.”

“An excess of homocysteine is known to affect levels of two of the main mediators of cellular methylation reactions, S-adenosyl methionine and methylene tetrahydrofolate.”

“ Homocysteine remethylation plays a key role in the synthesis of methionine and S-adenosine methionine.”

“RESULTS Fasting tH y, S AH and SAM we re significantly higher in patients compared with controls.”

“ SAM markedly enhanced CBS-mediated H2S production in vitro, especially when a combination of cysteine and homocysteine was used as substrates.”

“On the contrary, omega-3 fatty acids and some nutraceuticals, such as N-acetyl cysteine, taurine, or S-adenosyl-methionine , reduce both Hcy serum concentration and cardiovascular risk.”

“When cells were exposed to elevated insulin and glucose, homocysteine remethylation was enhanced, which consequently increased intracellular adoMet concentrations by inducing adoMet synthase activity.”