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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Homocysteine
drug:
Potassium Chloride
Research Papers that Mention the Interaction
“ HC in combination with Alx resulted in a more pronounced decline in insulin secretion, including that induced by 20 mM alanine, by 43% (P<0.001) and 30 mM KCl by 60% (P<0.001), compared with control culture.”
Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan.“ Homocysteine also dose-dependently inhibited insulinotropic responses to a range of glucose-dependent secretagogues including nutrients (alanine, arginine, 2-ketoisocaproate), hormones (glucagon-like peptide-1 (7-36)amide, gastric inhibitory polypeptide and cholecystokinin-8), neurotransmitter (carbachol), drug (tolbutamide) as well as a depolarising concentration of KCl or elevated Ca2+.”
“The contractile response to both phenylephrine (Phe) (−36%) and KCl (−18%) was significantly reduced in arteries that were incubated with Hcy (10−4 M, 30 minutes), compared with controls (P < 0.05).”
“Insulinotropic responses to alanine, arginine, 2-ketoisocaproate, elevated Ca2+, tolbutamide, potassium chloride (KCl), forskolin, and phorbol 12-myristate 13-acetate were also significantly reduced by homocysteine.”
Homocysteine-Induced Impairment of Insulin Secretion From Clonal Pancreatic BRIN-BD11 &bgr;-Cells Is Not Prevented by Catalase“ L-Homocysteinethiolactone inhibits methylation of membrane phospholipids and depresses the contractile response to KCl and to norepinephrine.”
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