Possible Interaction: Homocysteine and Polyunsaturated Fatty Acids

“OBJECTIVES Vitamin B-12 and n-3 polyunsaturated fatty acids (PUFA) decrease blood homocysteine (Hcy) concentrations.”

“Supplementation with PUFA n-3 led to a significant decrease in plasma tHcy (-29%, P < .01) and TG (-28%, P < .05) levels, as well as to a significant decrease in MA (-24%, P < .05).”

“… n–3 polyunsaturated fatty acids (n–3 PUFAs) as compared to corn oil … following an acute myocardial infarction (MI) may reduce plasma total homocysteine (p-tHcy), ultrasensitive C-reactive protein (µCRP), and the adhesive properties of the … E-selectin (sE-selectin) and soluble intercellular adhesion molecule-1 (sICAM-1).”

“Our earlier studies suggest that altered metabolism of folic acid, vitamin B12 and long chain polyunsaturated fatty acid (LCPUFAs) in the one carbon cycle increases homocysteine levels in preeclampsia.”

“Omega-3 polyunsaturated fatty acid supplementation was associated with a modest reduction in homocysteine.”

“BackgroundPrevious studies showed that plasma n-3 polyunsaturated fatty acid PUFA ) was negatively associated with plasma homocysteine (Hcy).ObjectiveWe investigated the regulatory effect of n-3 PUFA on mRNA expression of the critical genes encoding the enzymes involved in Hcy metabolism.”

“BACKGROUND AND AIM Dietary n-3 polyunsaturated fatty acids PUFAs ) are associated with decreased plasma homocysteine (Hcy), an important biomarker for cardiovascular disease.”

“We found that plasma Hcy concentration was negatively correlated with (n-3) PUFA intake (r = -0.117; P = 0.022), and the ratio of (n-3):(n-6) PUFA in the diet (r = -0.122; P = 0.009).”

“In the partial correlation analysis, after … vitamin B12 and folate concentration, plasma Hcy was significantly negatively correlated with the plasma phospholipid concentration of 22∶6n−3 (r=−0.205, …), total n−3 (r=−0.182, P=0.038) and the ratio n−3/n−6 PUFA (r=−0.….048).”

“… Hcy … PUFA 20∶5n−3 (r=−0.226, P=0.009), 22∶5n−3 (r=−0.182, P=0.036), 22∶6n−3 (r=−0.286, P=…−6 PUFA (r=−0.265, P=0.002), and significantly positively correlated with 20∶4n−6 (r=0.180, P=0.037).”