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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Homocysteine
drug:
Phospholipids
Research Papers that Mention the Interaction
“In omnivores, plasma PL 18 : 1n-7 (r 0·237, P= 0·030) was significantly positively associated with plasma Hcy.”
“In vegetarians, plasma PL 22 : 6n-3 (r − 0·257, P= 0·046) was significantly negatively associated with plasma Hcy.”
Associations of plasma phospholipid fatty acids with plasma homocysteine in Chinese vegetarians“In the partial correlation analysis, after … vitamin B12 and folate concentration, plasma Hcy was significantly … the plasma phospholipid concentration of 22∶6n−3 (r=−0.205, P=0.019), total n−3 (r=−0.….038) and the ratio n−3/n−6 PUFA (r=−0.174, P=0.048).”
“ L-Homocysteinethiolactone inhibits methylation of membrane phospholipids and depresses the contractile response to KCl and to norepinephrine.”
Effect of L-methionine on contractile response, calcium influx and calcium channel blocking agents in the rat aorta.“The transmethylase inhibitor, homocysteine , caused a marked decrease in the accumulation of methylated phospholipids under basal conditions, which was correlated with as much as a 50-fold increase in sperm sensitivity to the attractant.”
“Inhibitors of methyltransferases, i.e., 3-deaza-adenosine plus L-homocysteine thiolactone, inhibited not only phospholipid methylation but also DAG formation and GIF release.”
“In both IgE-mediated and GEF-induced histamine release, inhibitors of methyltransferases, such as 3-deaza adenosine and L-homocysteine thiolactone, inhibited not only phospholipid methylation but also the cAMP rise and subsequent Ca2+ uptake and histamine release.”
“Inhibitors of phospholipid methylation (100 microM adenosine + 10 microM L-homocysteine thiolactone + 10 microM erythro-9[2-hydroxy-3-nonyl]adenine) significantly decreased TSH-stimulation of phospholipid methylation but not T3/T4 secretion.”
“The phospholipid methylation activity was inhibited by the addition of S-adenosyl-L-homocysteine or by L-homocysteinethiolactone.”
“ HCYS and 3-DZA inhibited chemotaxis, phospholipid methylation , and protein carboxymethylation in a dose-dependent manner.”
“Inhibition of phospholipid methylation by methyltransferase inhibitors, 3-deazaadenosine and homocysteine thiolactone, almost completely blocks the influx of Ca 2+ , and release of arachidonic acid and histamine.”
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