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Last Updated: 2 years ago

Possible Interaction: Homocysteine and Phenytoin

supplement:

Homocysteine

Research Papers that Mention the Interaction

CONCLUSIONS Ph nytoin mo notherapy may cause a significant increase in the levels of ser um homocysteine an d a significant decrease in the serum folate and vitamin B12 levels in children with epilepsy, and the significant changes in above mentioned parameters occur early in the course of treatment.
Clinical laboratory  •  2017  |  View Paper
We should keep in mind, for example, that exposure to any folate or vitamin B6 antagonist, such as methotrexate, phenytoin , estrogens, tobacco, or theophylline, could significantly raise blood concentrations of homocysteine thus strongly increasing the risk of arterial and venous thrombotic events.
Annals of emergency medicine  •  2008  |  View Paper
By one-way ANOVA, subjects on phenytoin monotherapy had significantly higher levels of s-Hcy than those on other AEDs (F=5.89, p=.016).
Seizure  •  2007  |  View Paper
Additionally, the underlying mechanism for homocysteine increase seems to be a decrease of cofactor molecules in patients using carbamazepine and phenytoin (pyridoxal 5'-phosphate and folic acid, respectively).
Seizure  •  2006  |  View Paper