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“ Homocysteine inhibited not only the endothelial-derived NO as stimulated by ACh, but also the bioactivity of exogenously supplied NO by SNOHcy, SNOCys and SNP.”
“We found that Hcy (0.5 mM) markedly reduced the increase in haem oxygenase activity and HO‐1 protein expression induced by sodium nitroprusside (SNP, 0.5 mM) but did not affect HO‐1 activation mediated by S‐nitroso‐N‐acetyl‐penicillamine.”