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Last Updated: a month ago

Possible Interaction: Homocysteine and Methotrexate

supplement:

Homocysteine

Research Papers that Mention the Interaction

In the univariate linear regression, the global toxicity score was associated with a significant rise in plasma HCY concentrations within 48 h after MTX administration (β = 0.4; R2 = 0.12; p = 0.02).
Advances in clinical and experimental medicine : official organ Wroclaw Medical University  •  2018  |  View Paper
OBJECTIVE Interference of methotrexate (MTX) with the metabolism of homocysteine may contribute to MTX neurotoxicity.
International journal of clinical pharmacology and therapeutics  •  2007  |  View Paper
CONCLUSIONS Low-dose MTX treatment in RA patients leads to an increased plasma homocysteine level.
Rheumatology  •  2002  |  View Paper
Plasma tHcy is a sensitive indicator of the antifolate effect of MTX , as demonstrated by an increased plasma tHcy concentration.
Clinical chemistry  •  1998  |  View Paper
Plasma and red blood cell folate levels before methotrexate therapy were significantly negatively correlated with homocysteine levels.
Clinical pharmacology and therapeutics  •  1991  |  View Paper
The use of disease-modifying antirheumatic drugs (DMARDs), particularly methotrexate , increases homocysteinemia , reduces inflammation and improves lipid profiles, thus reducing the development of atherosclerosis and clinically overt CVD.
Autoimmunity reviews  •  2010  |  View Paper
We should keep in mind, for example, that exposure to any folate or vitamin B6 antagonist, such as methotrexate , phenytoin, estrogens, tobacco, or theophylline, could significantly raise blood concentrations of homocysteine thus strongly increasing the risk of arterial and venous thrombotic events.
Annals of emergency medicine  •  2008  |  View Paper
Plasma homocysteine level did significantly increase in AS patients under sulfasalazine or MTX treatment.
Clinical Rheumatology  •  2006  |  View Paper
Homocysteine concentrations increased after MTX administration by a median of 2.5 mumol/l (range 0.7-5.1).
Annals of the rheumatic diseases  •  2005  |  View Paper
Moreover, MTX interferes with the metabolic pathways of folates, excitatory amino acids, homocysteine , S-adenosylmethionine/S-adenosylhomocysteine, adenosine and biopterins, inducing biochemical alterations which have been associated with neurotoxic symptoms.
Chemotherapy  •  2003  |  View Paper
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