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Last Updated: 7 months ago

Possible Interaction: Homocysteine and Methotrexate

supplement:

Homocysteine

Research Papers that Mention the Interaction

In the univariate linear regression, the global toxicity score was associated with a significant rise in plasma HCY concentrations within 48 h after MTX administration (β = 0.4; R2 = 0.12; p = 0.02).
Advances in clinical and experimental medicine : official organ Wroclaw Medical University  •  2018  |  View Paper
OBJECTIVE Interference of methotrexate (MTX) with the metabolism of homocysteine may contribute to MTX neurotoxicity.
International journal of clinical pharmacology and therapeutics  •  2007  |  View Paper
In a multiple regression model there was an association between the alteration in Hcy level over 0–12 months and MTX treatment, as well as the alteration in CRP, adjusted for B‐vitamin treatment.
Scandinavian journal of rheumatology  •  2003  |  View Paper
In cell culture studies, MTX inhibits Hcy remethylation, leading to increased Hcy export to the medium (6)(7)(8) .
Clinical chemistry  •  1998  |  View Paper
Recently, it has been postulated that homocysteine may be a marker of the 'pharmacodynamic effect' of methotrexate , but studies attesting to this role are only now emerging.
Pharmacogenomics  •  2004  |  View Paper
Although its efficacy is widely attributed to a decrease in nucleotide biosynthesis (1), methotrexate is known to increase homocysteine (2), a compound associated with an elevated risk of heart disease, Alzheimer's disease (3), and neural tube defects (4).
Proceedings of the National Academy of Sciences of the United States of America  •  2003  |  View Paper
Specific clinical conditions like the use of antiepileptic drugs or methotrexate , renal failure, cancer, rheumatoid arthritis, and hypothyroidism may lead to elevated tHcy concentrations.
Pharmacological Reviews  •  2002  |  View Paper
We should keep in mind, for example, that exposure to any folate or vitamin B6 antagonist, such as methotrexate , phenytoin, estrogens, tobacco, or theophylline, could significantly raise blood concentrations of homocysteine thus strongly increasing the risk of arterial and venous thrombotic events.
Annals of emergency medicine  •  2008  |  View Paper
Plasma homocysteine level did significantly increase in AS patients under sulfasalazine or MTX treatment.
Clinical Rheumatology  •  2006  |  View Paper
Homocysteine concentrations increased after MTX administration by a median of 2.5 mumol/l (range 0.7-5.1).
Annals of the rheumatic diseases  •  2005  |  View Paper
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