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“After 15 weeks, compared with the normal control group, serum concentrations of Hcy were significantly increased by 1.15‑, 2.54‑ and 1.17‑fold (P<0.05) in the ApoE‑/‑ control group, Meth group and Meth‑F group, respectively.”
“In contrast, homocysteine plays an inhibitory role in the metR-mediated activation of the metH gene , decreasing expression of a metH-lacZ gene fusion threefold.”
“In the presence of purified MetR protein, which is known to regulate the expression of these genes, homocysteine activates metE expression and inhibits both metR and metH expression.”