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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Mecobalamin
Research Papers that Mention the Interaction
“CONCLUSION The benefit of me hylcobalamin ad ministration on lowering plasma tHc y le vels in HD patients was remarkable.”
Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation.“Finally, a short-term treatment with a high dose of methylcobalamin , which reduces Hcy levels, was effective in improving compound motor action potentials in patients with ALS.”
“Supplementation of methylcobalamin and folic acid can effectively reduce Hcy level and thereby prevent the occurrence of ischemic stroke.”
“ MeCbl decreases Hcy induced motor neuron death in vitro in a hybrid cell line derived from motor neuron-neuroblastoma and may play a role in the treatment of late stage ALS where HCy levels are increased in animal models of ALS.”
“ MeCbl inhibited caspase 3/7 activation by homocysteine in a time- and dose-dependent manner, whereas MTHF had no effect.”
Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death.“The second-order rate constant for demethylation of methylcobalamin by Hcy is elevated 60-fold and that for methylation of cob(I)alamin is elevated 120-fold.”
Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase.
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