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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Mannitol
Research Papers that Mention the Interaction
“Co-incubation with extracellular free-radical inhibitors (superoxide dismutase, catalase and mannitol ) markedly reduced the effect of Hcy on ET-1 production.”
Homocysteine-induced decrease in endothelin-1 production is initiated at the extracellular level and involves oxidative products.“ HCY plus FeSO(4) potentiated KCl-induced vasoconstriction in a concentration-dependent manner; pretreatment with mannitol significantly reduced this vasospastic effect.”
“Pre‐treatment with mannitol significantly suppressed the vasospastic effect of Hcy.”
“Removal of endothelium (P < 0.05), pretreatment with a nitric oxide (NO) synthesis inhibitor (l-N(G)-monomethylarginine, 200 microM, P < 0.001), or pretreatment with a hydroxyl radical ((*)OH) scavenger mannitol , 10 mM, P < 0.001) significantly attenuated contraction potentiated by Hcy plus Fe(2+).”
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