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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Homocysteine and Leucovorin



Research Papers that Mention the Interaction

Folic acid and folinic acid decreased the blood homocysteine levels by 33.0% and 28.7%, respectively (P < .001).
Iranian journal of kidney diseases  •  2011  |  View Paper
5-FULV on day 1 … of the tHcy level from 12.5 micromol/liter (10.4-15.1 micromol/liter; geometric mean with 95% confidence interval of the mean) …-11.1 micromol/liter) in 24 h. tHcy remained stable at this level after the second administration of 5-FULV.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  1998  |  View Paper
FnA supplementation, with or without methionine restriction, reduced the level of tHcy and did not affect intracellular AdoMet levels.
Nutrients  •  2018  |  View Paper
Folinic acid resulted in a non-significant decrease in homocysteine (21 +/- 6 vs 28 +/- 18 micromol/l, P = 0.16) and diastolic blood pressure was significantly reduced (P = 0.05).
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association  •  2006  |  View Paper
The administration of IV folinic acid induces a reduction of homocysteine levels subordinate to the inflammatory status of the patient.
Kidney international. Supplement  •  2005  |  View Paper
dose of folinic acid and vitamin B12, show significantly lower plasma levels of tHcy than non-supplemented patients.
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia  •  2002  |  View Paper
CONCLUSIONS Low doses of folinic acid given intravenously to dialysis patients reduced their levels of p-tHcy and S-MDA and thus improved their cardiovascular risk profile.
Journal of internal medicine  •  2002  |  View Paper
These results suggest that 5-formyltetrahydrofolate inhibits serine hydroxymethyltransferase activity in vivo and that serine synthesis and homocysteine remethylation compete for one-carbon units in the cytoplasm.
The Journal of Biological Chemistry  •  1997  |  View Paper