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Last Updated: 2 years ago

Possible Interaction: Homocysteine and Kynurenic Acid

Research Papers that Mention the Interaction

Recently, it was revealed that kynurenic acid counteracts the harmful effects of homocysteine on endothelium cells in vitro.
Postepy higieny i medycyny doswiadczalnej  •  2012  |  View Paper
The addition of KYNA significantly increased endothelial cell migration and proliferation, which is diminished by homocysteine.
Pharmacological reports : PR  •  2009  |  View Paper
Glutamate agonists, l-glutamate and d l-homocysteine significantly decreased KYNA production.
Neurochemical Research  •  2005  |  View Paper
DL‐Homocysteine inhibited the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II, whereas S‐adenosylhomocysteine reduced only the activity of KAT II.
High concentrations of DL‐homocysteine (20 mM) applied via microdialysis probe decreased KYNA levels in rabbit hippocampus; this effect was antagonized partially by an antagonist of group I metabotropic glutamate receptors, LY367385.
In rat cortical slices, DL‐homocysteine enhanced (0.1–0.5 mM) or inhibited (concentration inducing 50% inhibition [IC50] = 6.4 [5.5–7.5] mM) KYNA production.
DL‐homocysteine (1.… KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 (P < 0.01; 15 min) and 11.4 ± 1.… min) in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 (P < 0.01; 15 min) in rat hippocampus.
Journal of neuroscience research  •  2005  |  View Paper
DL-homocysteine seems to modulate the production of kynurenic acid both directly and indirectly, possibly following the conversion to S-adenosylhomocysteine.
In rat aortic rings, DL-homocysteine at 40-100 microM enhanced, whereas at >or=400 microM decreased the synthesis of kynurenic acid.
European journal of pharmacology  •  2005  |  View Paper
d,l-Homocysteine and l-homocysteine sulphinic acid lowered KYNA production in BAEC.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper