supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Kynurenic Acid
Research Papers that Mention the Interaction
“Recently, it was revealed that kynurenic acid counteracts the harmful effects of homocysteine on endothelium cells in vitro.”
[Kynurenic acid--a new tool in the treatment of hiperhomocysteinemia and its consequences?].“The addition of KYNA significantly increased endothelial cell migration and proliferation, which is diminished by homocysteine.”
Kynurenic acid protects against the homocysteine-induced impairment of endothelial cells.“Glutamate agonists, l-glutamate and d l-homocysteine significantly decreased KYNA production.”
“ DL‐Homocysteine inhibited the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II, whereas S‐adenosylhomocysteine reduced only the activity of KAT II.”
“High concentrations of DL‐homocysteine (20 mM) applied via microdialysis probe decreased KYNA levels in rabbit hippocampus; this effect was antagonized partially by an antagonist of group I metabotropic glutamate receptors, LY367385.”
“In rat cortical slices, DL‐homocysteine enhanced (0.1–0.5 mM) or inhibited (concentration inducing 50% inhibition [IC50] = 6.4 [5.5–7.5] mM) KYNA production.”
“… DL‐homocysteine (1.… KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 (P < 0.01; 15 min) and 11.4 ± 1.… min) in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 (P < 0.01; 15 min) in rat hippocampus.”
“ DL-homocysteine seems to modulate the production of kynurenic acid both directly and indirectly, possibly following the conversion to S-adenosylhomocysteine.”
“In rat aortic rings, DL-homocysteine at 40-100 microM enhanced, whereas at >or=400 microM decreased the synthesis of kynurenic acid.”
“d,l-Homocysteine and l-homocysteine sulphinic acid lowered KYNA production in BAEC.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback