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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
supplement:
Isoleucine
Research Papers that Mention the Interaction
“Growth inhibition is believed to arise as a result of partial starvation for isoleucine , which occurs because Hcy perturbs the biosynthesis of this amino acid.”
“The induction of cspA by Hcy was suppressed when isoleucine was included in the growth medium.”
“These data suggest that the induction of CspA expression in the presence of Hcy occurs because of a limitation for isoleucine.”
Global effects of homocysteine on transcription in Escherichia coli: induction of the gene for the major cold-shock protein, CspA.“Enzyme assays revealed that the first step of the isoleucine biosynthetic pathway, catalyzed by threonine deaminase, was sensitive to inhibition by Hcy.”
“ Isoleucine could reverse the effects of Hcy on the cytoplasmic pools of valine and alanine.”
“The last intermediate of the isoleucine biosynthetic pathway, α-keto-β-methylvalerate , could also alleviate the growth inhibition caused by Hcy.”
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