Possible Interaction: Homocysteine and Hydrogen Peroxide

“The oxidative damage mediated by hydrogen peroxide production during the metal-catalyzed oxidation of homocysteine is to date considered to be one of the major pathophysiological mechanisms for this association.”

“The observations that (i) homocysteine and H2O2, but not … in mitochondrial RNA levels, (ii) intracellular levels of H2O2 were significantly … presence of homocysteine and Cu2+, and (iii) catalase, but not free radical scavengers, prevented a decrease … levels, provide evidence that homocysteine and H2O2 act synergistically to cause mitochondrial damage.”

“It is now documented that homocysteine damages human endothelial cells in culture, possibly by producing hydrogen peroxide in an oxygen‐dependent reaction.”

“We have examined whether the toxic effects of homocysteine on cultured endothelial cells could result from the formation and action of hydrogen peroxide.”

“Cytotoxicity of hydrogen peroxide significantly increased in HUVEC cells pre-treated with Hcy for 24 h. These data indicate that Hcy induces an increase in cellular ferritin level, and the process is mediated by alterations in Akt-FOXO3a signaling pathway.”

“ Homocysteine auto-oxidation produces H2O2 leading to LDL-TBARS increase.”

“Oxidation of homocysteine to homocystine is accompanied with production of hydrogen peroxide inducing damage of endothelium through oxidative stress.”

“Moreover, we found that hydrogen peroxide (H2O2) mimicked the effect of Hcy on TRPML1 channel activity, lysosome-MVB interaction, and exosome secretion in podocytes.”

“It has been previously established that HCY exacerbates damage to motor neurons from reactive oxygen species (ROS) such as hydrogen peroxide.”

“Recently it was shown that the presence of rat blood plasma (as well as of …-buffer (pH 8.5), 0.29 mM EDTA, 19.2 mM sodium azide, 1 mM DL-homocysteine (Hcy), and 198 mM hydrogen peroxide (incubation at … decrease in Hcy concentration caused by addition of H2O2.”