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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Ghrelin
Research Papers that Mention the Interaction
“ Homocysteine significantly reduced eNOS expression, whereas ghrelin cotreatment effectively restored eNOS expression to the control levels.”
“Superoxide anion levels, which were increased by 100% with Hcy , returned to control levels with ghrelin cotreatment.”
“The addition of ghrelin to Hcy had a protective effect, with 61.6% relaxation, which was similar to controls (64.7%).”
Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells.“In addition, Western blot assay showed that NF‐κB (nuclear factor κB) and cleaved‐caspase 3 expression were elevated, and PCNA (proliferating cell nuclear antigen) and eNOS (endothelial nitric oxide synthase) expression were decreased after treatment with HCY , which was significantly reversed by pretreatment with ghrelin.”
Effects of ghrelin on homocysteine‐induced dysfunction and inflammatory response in rat cardiac microvascular endothelial cells“The addition of Rb1 to Hcy also greatly reversed Hcy-induced downregulation of ghrelin and eNOS expression.”
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