Possible Interaction: Homocysteine and Folate

“The increased intake of folate from wholegrain bread was inversely associated with a reduced concentration of p-tHcy (P = 0.017).”

“Daily supplementation with vitamin B12 and folate , which are the cofactors of the enzymatic reactions involved in Hcy metabolism, can lower plasma levels of Hcy , so it is recommended to take these vitamins in case of deficiency along with Iso to prevent premature occlusive vascular disease.”

“BACKGROUND Elevated concentrations of homocysteine and low concentrations of folate may lead to a proinflammatory state that could explain their relation to vascular disease risk.”

“In the treated group, significant negative correlations were observed between homocysteine and folate values (r=-0.586, p=0.017) and between homocysteine and Vitamin B12 values (r=-0.672, p=0.004).”

“ Folate caused a significant decrease in homocysteine concentration.”

“We detected a trend toward a significant inverse relationship between baseline Hcy and folate levels.”

“BACKGROUND Hyperhomocysteinemia is a frequent finding after cardiac transplantation, but increased folate intake induces a decrease in total homocysteine concentrations.”

“RESULTS In group 2, fo ate tr eatment significantly decreased hom ocysteine le vels by 27.8% (12.2+/-1.2 vs 8.8+/-0.7 micromol/l; P<0.01).”

“However, 5 mg/day folate supplementation normalized Hcy in 10% of cases and reduced Hcy levels in another 21%.”

“Co-administration of folate decreased tHcy to 10.6 μmol/l.”

“ConclusionCo-administration of folate to fenofibrate therapy has the potential to reverse the fibrate-induced elevation of tHcy.”

“In our study we aimed to find out whether the folate co-administration would modify the fibrate-induced elevation of tHcy.”