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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Fenofibrate
Research Papers that Mention the Interaction
“ Fenofibrate use was associated with a 6% increase in high-density lipoprotein cholesterol, a 28% decrease in triglycerides, a 5% decrease in low-density lipoprotein cholesterol, and a 55% increase in plasma homocysteine (tHcy).”
Effect of fenofibrate-mediated increase in plasma homocysteine on the progression of coronary artery disease in type 2 diabetes mellitus.“ Fenofibrate significantly lowered plasma cholesterol, triglyceride and fibrinogen (P<0.001), and elevated HDL-cholesterol and homocysteine (P<0.001).”
“ Fenofibrate increased serum homocysteine (HCY) by 36.5%.”
“ Fenofibrate increases plasma homocysteine.”
“Since tHcy is considered an emerging cardiovascular risk factor, the ability of FEN to increase plasma tHcy levels could potentially mitigate the potential of this drug to protect against cardiovascular disease.”
“ Fenofibrate induced a significant increase in both homocysteine and cysteine plasma levels (+35.8 and +18%, respectively, P<0.0001); by contrast, cysteinylglycine remained stable.”
“After fenofibrate plus placebo the increase in homocysteine concentration was 44+/-47%.”
“The increase in homocysteine in response to fenofibrate may counteract the cardioprotective effect of lipid lowering.”
“A 44% and 17.5% increase of homocysteine occurred in patients treated either with fenofibrate or bezafibrate.”
“Abstract Background: The lipid-lowering effect of fenofibrate is accompanied by a rise in plasma homocysteine (HCY), a potential risk factor for venous thromboembolism (VTE).”
“ Fenofibrate may predispose individuals with high pretreatment HCY towards VTE.”
“This finding raised the question whether high Hcy may influence HDL function and counteract benefits of fenofibrate on cardiovascular outcomes.”
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