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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Homocysteine and Epoprostenol

supplement:

Homocysteine

Research Papers that Mention the Interaction

In-vitro studies have demonstrated that homocysteine decreases the production or bioavailability of vasodilator autacoids, such as prostacyclin and NO.
European journal of biochemistry  •  1999  |  View Paper
By contrast, S-adenosylhomocysteine and protein-bound homocysteine specifically inhibited prostacyclin production by cells cultured in medium containing 20% fetal calf serum.
Thrombosis and haemostasis  •  1993  |  View Paper
Homocysteine at 10 mM and 1 mM concentration inhibited PGI2 synthesis from both exogenous and endogenous arachidonic acid.
Prostaglandins, leukotrienes, and medicine  •  1986  |  View Paper
RESULTS Several studies have shown that altered levels of Hc , t hrough AA release and metabolism, can influence the synthesis and the activity of prostaglandins (PGs), pro stacyclin (P GI₂), thromboxane (TXA), epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs).
Endocrine, metabolic & immune disorders drug targets  •  2020  |  View Paper