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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
drug:
Epoprostenol
Research Papers that Mention the Interaction
“In-vitro studies have demonstrated that homocysteine decreases the production or bioavailability of vasodilator autacoids, such as prostacyclin and NO.”
Homocysteine decreases endothelin-1 production by cultured human endothelial cells.“By contrast, S-adenosylhomocysteine and protein-bound homocysteine specifically inhibited prostacyclin production by cells cultured in medium containing 20% fetal calf serum.”
“ Homocysteine at 10 mM and 1 mM concentration inhibited PGI2 synthesis from both exogenous and endogenous arachidonic acid.”
Peroxide mediated effects of homocysteine on arterial prostacyclin synthesis.“RESULTS Several studies have shown that altered levels of Hc , t hrough AA release and metabolism, can influence the synthesis and the activity of prostaglandins (PGs), pro stacyclin (P GI₂), thromboxane (TXA), epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs).”
The interaction Between Arachidonic Acid Metabolism and Homocysteine.
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