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Last Updated: 2 years ago

Possible Interaction: Homocysteine and Cupric Cation

supplement:

Homocysteine

supplement:

Cupric Cation

Research Papers that Mention the Interaction

There were two mechanisms by which homocysteine caused DNA damage in the presence of Cu(II).
Oncogene  •  2003  |  View Paper
The redox processes between Cu(II) and hCys , in a molar ratio > or =1:3 led to formation of a second yellow Cu(I)hCys complex.
Journal of inorganic biochemistry  •  2003  |  View Paper
Homocysteine (HCY) reduces free Cu2+ , potentiating its cell‐damaging property.
FEBS letters  •  2002  |  View Paper
D L-Homocysteine (HCY, 1 mM) and glutathione (GSH, 1 mM) similarly inhibited Cu2+ -dependent, while facilitating Fe3+-dependent, oxidation of LDL.
Biochimica et biophysica acta  •  1997  |  View Paper
The competitive coordination between Hcy and Cu(II ) allows the fluorescence of the polymer off to on.
Analytical chemistry  •  2020  |  View Paper
The data support the conclusion that O-2, generated by the reaction of homocysteine with Cu2+ , inhibits NO-related cerebrovascular responses by scavenging NO, perhaps through peroxynitrite formation.
We studied whether homocysteine , in the presence of Cu2+ , alters reactivity of cerebral circulation and, if so, whether this effect depends on O-2 generation.
The American journal of physiology  •  1998  |  View Paper
The increment in mitochondrial O2(-) production was totally and concentration-dependently prevented by the addition of the complexes formed between Cu(II) and the disulfides of glutathione, homocysteine , or a-dehydro-lipoic acid (20µM each); comparatively, the Cu(II)-cystine complex exerted a weaker protection.
Free radical biology & medicine  •  2014  |  View Paper
The interaction between homocysteine (HCysSH) and Cu(II) leads to the formation of a yellow complex [Cu(I)(HCysS-SCysH)2]Cl (1) after redox processes in the Cu(II)-homocysteine system resulting in dimerization of the ligand and formation of a mononuclear Cu(I) complex with two dimers.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy  •  2004  |  View Paper
The data support the conclusion that [Formula: see text], generated by the reaction of homocysteine with Cu2+ , inhibits NO-related cerebrovascular responses by scavenging NO, perhaps through peroxynitrite formation. [
We studied whether homocysteine , in the presence of Cu2+ , alters reactivity of cerebral circulation and, if so, whether this effect depends on[Formula: see text] generation.
American journal of physiology. Regulatory, integrative and comparative physiology  •  1998  |  View Paper