Possible Interaction: Homocysteine and Cupric Cation

“There were two mechanisms by which homocysteine caused DNA damage in the presence of Cu(II).”

“The redox processes between Cu(II) and hCys , in a molar ratio > or =1:3 led to formation of a second yellow Cu(I)hCys complex.”

“ Homocysteine (HCY) reduces free Cu2+ , potentiating its cell‐damaging property.”

“D L-Homocysteine (HCY, 1 mM) and glutathione (GSH, 1 mM) similarly inhibited Cu2+ -dependent, while facilitating Fe3+-dependent, oxidation of LDL.”

“The competitive coordination between Hcy and Cu(II ) allows the fluorescence of the polymer off to on.”

“The data support the conclusion that O-2, generated by the reaction of homocysteine with Cu2+ , inhibits NO-related cerebrovascular responses by scavenging NO, perhaps through peroxynitrite formation.”

“We studied whether homocysteine , in the presence of Cu2+ , alters reactivity of cerebral circulation and, if so, whether this effect depends on O-2 generation.”

“The increment in mitochondrial O2(-) production was totally and concentration-dependently prevented by the addition of the complexes formed between Cu(II) and the disulfides of glutathione, homocysteine , or a-dehydro-lipoic acid (20µM each); comparatively, the Cu(II)-cystine complex exerted a weaker protection.”

“The interaction between homocysteine (HCysSH) and Cu(II) leads to the formation of a yellow complex [Cu(I)(HCysS-SCysH)2]Cl (1) after redox processes in the Cu(II)-homocysteine system resulting in dimerization of the ligand and formation of a mononuclear Cu(I) complex with two dimers.”

“The data support the conclusion that [Formula: see text], generated by the reaction of homocysteine with Cu2+ , inhibits NO-related cerebrovascular responses by scavenging NO, perhaps through peroxynitrite formation. [”

“We studied whether homocysteine , in the presence of Cu2+ , alters reactivity of cerebral circulation and, if so, whether this effect depends on[Formula: see text] generation.”