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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
supplement:
Creatine Monohydrate
Research Papers that Mention the Interaction
“ Creatine supplementation (CrS) reduces plasma homocysteine levels and enhances vascular reactivity in the microcirculation.”
“Laser speckle contrast imaging coupled with acetylcholine skin iontophoresis was used to evaluate cutaneous microvascular reactivity, and intravital video‐microscopy was used to evaluate skin capillary density and reactivity before and after CrS. We demonstrated that CrS reduces the plasma levels of homocysteine and increases those of folic acid.”
Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets“OBJECTIVE: To determine if oral creatine supplements will lower the concentration of total plasma homocysteine (tHcy).”
“Additionally, CrS is able to influence blood levels of homocysteine , resulting in presumed effects on vascular endothelial function.”
“Unexpectedly, creatine supplementation (alone or in combination with l-arginine) was associated with an 11–20% increase in homocysteine concentration (p < 0.05), which was not attributable to worsened renal function, providing evidence against an effect of creatine on decreasing methylation demand.”
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