Possible Interaction: Homocysteine and Calcium Supplement

“ Hcy increases intracellular calcium and activates calpain and calpain-associated mitochondrial (mt) abnormalities have been identified in HHcy.”

“Lactose and calcium in conjunction with Hcy from consumption of non-fat milk may also contribute to calcification of the arteries.”

“ Homocysteine (Hcy) may disturb calcium (Ca2+) cytosolic regulation in endothelial cells, a process that can directly affect the synthesis of vasoactive substances, such as nitric oxide (NO).”

“In addition the treatment of platelets with homocysteine caused intracellular calcium rise and protein kinase C activation.”

“In FURA 2‐loaded platelets, HCy induced a dose‐dependent intracellular calcium rise suggesting that the calcium elevation promoted by HCy could participate in the cPLA2 activation, leading to arachidonic acid release and TXB2 formation.”

“After adjustment for the same confounders, subsequent regression analysis confirmed significant associations of Hcy with DPD and Ca.”

“In vitro, as compared to calcifying medium alone, Hcy treatment further increased alkaline phosphatase activity, calcium content , and calcium nodule number in human aorta vascular smooth muscle cells (HA-VSMCs), all blocked by IMD or PBA pretreatment.”

“Incubation of freshly isolated cardiomyocytes with 0.1 mM L-homocysteine significantly decreased the amplitude of the calcium transient and slowed the time to half relaxation.”

“In another series of experiments, Hcy increased the intracellular concentration of calcium in a dose-dependent manner, which was attenuated by MK-801, an N-methyl-D-aspartate (NMDA) receptor inhibitor, but not by bicuculline, a gamma-aminobutyric acid receptor inhibitor.”

“Inhibition of phospholipid methylation by methyltransferase inhibitors, 3-deazaadenosine and homocysteine thiolactone, almost completely blocks the influx of Ca 2 + , and release of arachidonic acid and histamine.”