Possible Interaction: Homocysteine and Atorvastatin

“Apart from lowering total and LDL cholesterol, atorvastatin decreased plasma levels of uric acid, hsCRP, homocysteine , and fibrinogen, with no difference between treatment groups.”

“Conclusion: The effects of atorvastatin on TGs and HDL-C depend on changes in Hcy levels.”

“In group 2, atorvastatin exerted also a more potent impact on hsCRP, fibrinogen and homocysteine.”

“Moreover, atorvastatin caused a decrease in plasma levels/urinary loss of uric acid, hsCRP, homocysteine and UACR, and insignificantly increased circulating levels of 25-hydroxyvitamin D. The drug produced no effect on plasma fibrinogen.”

“Intensive lipidlowering therapy (rosuvastatin or atorvastatin , or atorvastatin + ezetimibe combination therapy) decreased Hcy levels, lipid peroxidation and LDL-C levels [1].”

“ Atorvastatin (10 μmol/L) also antagonized Hcy (1 mmol/L for 30 min) induced activation of NADPH oxidase (2.57±0.49 vs 3.33±0.6, P<0.05).”

“… Atorvastatin inhibited endothelial cell … 1 mmol/L Hcy in a dose-dependent manner and the maximal inhibitory effect was reached at 100 μmol/L. Atorvastatin (10 μmol/L) significantly … mmol/L for 30 min) induced ROS accumulation (3.17±0.33 vs 4.34±0.31, P<0.05).”

“…,Atorvastatin … homocystein concentrations with 19.41% (baseline 17.7 +/- 11.16 microM/l) (p < 0.01), and CRP with 21.9% (baseline 4.8 +/- 4.19 ….01 and TBARS with 52% (baseline 0.87 +/- 0.89 nM/ml) p < 0.001, but did not influence sICAM and Ab oxLDL.”

“The results showed that atorvastatin inhibited the migration of VSMCs induced by Hcy , which was reversed by the mevalonate.”

“The detrimental effects of Hcy were attenuated by atorvastatin pretreatment.”

“These effects of Hcy on EPCs were reversed by atorvastatin in a does-dependent manner.”

“Exendin-4 (1 microg kg-1, ip) and atorvastatin (30 mg kg-1, po) treatments significantly attenuated increase in serum glucose and homocysteine but their concentrations remained markedly higher than sham control value.”