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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“There is evidence that an increase in plasma homocysteine may increase the formation of asymmetric dimethylarginine ( ADMA ), an inhibitor of nitric oxide synthase.”
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.“Our results suggest that ADMA may be a mediator of the atherogenic effects of homocysteine.”
“In the combined patient and control groups a highly significant positive correlation was found between the plasma concentrations of homocysteine and ADMA (r=0.782, P<0.0001).”
“ Homocysteine has been proposed to inhibit the catabolic enzyme of ADMA , dimethylarginine dimethylaminohydrolase (DDAH), but the mechanism of this inhibition has not been fully elucidated.”
“Finally, homocysteine , either directly or by increasing oxidative stress, may promote release of free ADMA by accelerating protein degradation.”
“The metabolic pathways of ADMA and homocysteine are strongly intertwined.”
“There is experimental evidence that homocysteine may affect endothelium-dependent vascular function by increasing the formation of ADMA.”
“ ADMA release by cultured endothelial cells was significantly increased in the presence of methionine or homocysteine.”
“Conclusions: Hcy and ADMA are significantly associated in RA.”
“It has been suggested that homocysteine leads to endothelial dysfunction by causing an accumulation of asymmetrical dimethyl arginine (ADMA), a potent endogenous nitric oxide (NO) synthase inhibitor of the l-arginine–NO pathway.”
“ HCY has been shown to inhibit the activity of endothelial dimethylaminohydrolase (DDAH), causing the accumulation of ADMA and the inhibition of nitric oxide synthesis.”
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