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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Homocysteine
supplement:
3-Nitrotyrosine
Research Papers that Mention the Interaction
“Studies have demonstrated that Hcy decreases bioavailability of endothelial nitric oxide (eNO), generates nitrotyrosine , and activates latent matrix metalloproteinase (MMP), instigating EE dysfunction.”
Role of Nitric Oxide in Matrix Remodeling in Diabetes and Heart Failure“ Homocysteine induces formation of the peroxynitrite biomarker nitrotyrosine.”
“Furthermore, we hypothesize that Hcy increases reactive oxygen species, generates nitrotyrosine , activates latent matrix metalloproteinase, and decreases the levels of endothelial nitric oxide in response to antagonizing PPAR-gamma.”
Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model.“ Nitrotyrosine expression was increased significantly by Hcy.”
“The results suggest that Hcy increased aortic wall stress by increasing nitrotyrosine and MMP-9 activity.”
“ HCY treatment for 24 hr significantly reduced cellular levels of the CAT-1 arginine transporter protein ( approximately 30%) and increased nitrotyrosine formation , whereas levels of eNOS protein and basal NOS activity were not altered.”
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