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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Homocysteine and 3-Nitrotyrosine

supplement:

Homocysteine

supplement:

3-Nitrotyrosine

Research Papers that Mention the Interaction

Studies have demonstrated that Hcy decreases bioavailability of endothelial nitric oxide (eNO), generates nitrotyrosine , and activates latent matrix metalloproteinase (MMP), instigating EE dysfunction.
Heart Failure Reviews  •  2004  |  View Paper
Homocysteine induces formation of the peroxynitrite biomarker nitrotyrosine.
Nitric oxide : biology and chemistry  •  2009  |  View Paper
Furthermore, we hypothesize that Hcy increases reactive oxygen species, generates nitrotyrosine , activates latent matrix metalloproteinase, and decreases the levels of endothelial nitric oxide in response to antagonizing PPAR-gamma.
Canadian journal of physiology and pharmacology  •  2005  |  View Paper
Nitrotyrosine expression was increased significantly by Hcy.
American journal of physiology. Heart and circulatory physiology  •  2005  |  View Paper
The results suggest that Hcy increased aortic wall stress by increasing nitrotyrosine and MMP-9 activity.
American journal of physiology. Lung cellular and molecular physiology  •  2003  |  View Paper
HCY treatment for 24 hr significantly reduced cellular levels of the CAT-1 arginine transporter protein ( approximately 30%) and increased nitrotyrosine formation , whereas levels of eNOS protein and basal NOS activity were not altered.
Medical science monitor : international medical journal of experimental and clinical research  •  2001  |  View Paper