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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Histidine
supplement:
Zinc Cation
Research Papers that Mention the Interaction
“ Free histidine (but not tryptophan or asparagine) and Zn2+ (but not Na+) prevented this interaction, confirming the key role of His-13 and His-14 in ganglioside binding.”
Deciphering the Glycolipid Code of Alzheimer's and Parkinson's Amyloid Proteins Allowed the Creation of a Universal Ganglioside-Binding Peptide“ Zn(II ) binds to the N(tau) atom of histidine and the peptide aggregates through intermolecular His-Zn-His bridges.”
“The inhibition of amidolytic plasmin activity by Zn2+ and Cu2+ was reduced in the presence of EDTA, histidine , or albumin.”
“For two histidines to interact with a Zn2+ ion, the alpha carbons must be separated by <13 A. This limits the separation of the subunits and provides a constraint on the possible quaternary structures of the channel.”
Location of a high affinity Zn2+ binding site in the channel of alpha1beta1 gamma-aminobutyric acidA receptors.“Increasing … of l‐histidine enhanced 65Zn flux into brain at [ Zn2+ ] values between 1 and 1,000 nM. The combined effect of [histidine] and [Zn2+] was best accounted for by a function of [ZnHis+], i.e., flux = 64.4 · [ZnHis+]/(390 + [ZnHis+]) + 0.00378 · [ZnHis+], with concentrations being nanomolar.”
“It is suggested that histidine is involved in the binding of the essential Zn2+ -ions.”
“A Zn(II) complex was found to exhibit greatly enhanced fluorescence in the presence of histidine but not in the presence of any other amino acids including cysteine.”
Highly selective fluorescent recognition of histidine by a crown ether-terpyridine-Zn(II) sensor.
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