Possible Interaction: Histidine and Tryptophan

“As demonstrated on several peptides, aromatic amino acid residues Trp, Tyr, Phe and His are targeted with high selectivity to Trp.”

“RESULTS The substitution of tr ptophan by his tidine pr oved to strongly modulate the antimicrobial activity, mainly by changing the peptide-to-membrane binding energy.”

“Our results show some differences in the nature of the interaction of the histidine and tryptophan in the transmembrane domains of BM2 and M2 ion channels.”

“Azaserine, l-2,4 diaminobutyric acid, l-histidine , and l-leucine, at low concentrations, increase the initial velocity of uptake of l-tryptophan but compete with l-tryptophan at high concentrations.”

“These structural data, in conjunction with potentiometric and kinetic studies on both mutants, reveal that histidine 55 is not essential for turnover but greatly disfavors the mechanistically unproductive binding of l-Trp to the oxidized enzyme allowing control of catalysis.”

“Infusion of methionine, tyrosine, phenylalanine, histidine and tryptophan (designated group 1) resulted in significant increases in the uptakes of tyrosine, phenylalanine and histidine.”

“Summary The presence of 1-tryptophan decreases the rate of intestinal absorption of L-histidine in the rat.”

“The conjugated planar rings of tyrosine and tryptophan may interact with histidine within the active site to provide stability upon enzyme-peptide binding.”

“The fragmentation scheme indicates that the gas-phase basicity of histidine is lower than that of radical tryptophan so that histidine is always pulling the proton away from tryptophan.”

“The ratio of histidine misincorporation at tryptophan sites in the proteome increased from 0.0007 to 0.03 over 300 days of continuous culture.”