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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Histidine
drug:
Sodium Chloride
Research Papers that Mention the Interaction
“Addition of 140 mM NaCl to solutions buffered with 10 mM l-histidine , pH 6.0, increased the amount of protein adsorbed.”
Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions.“The measured pK(a) of most histidines , whether in the protein or in model compounds, increased by 0.3 pH units or more between 0.02 M and 1.5 M NaCl.”
Salt effects on ionization equilibria of histidines in myoglobin.“The … histidine 119 and histidine 12 of the active site are unusually low and … 1.0 and 0.7 units to higher values when the NaCl concentration is changed from 0.1 M to 0.4 M, whereas … value of histidine 105 shifts only by about 0.2 units.”
“Screening of the charges on the surface and histidine units by adding NaCl influences the nucleation-and-growth process in a complicated fashion: at low pH, the growth is improved, while at high pH, the nucleation is limited.”
Subtle charge balance controls surface-nucleated self-assembly of designed biopolymers.“For early culture times (6 h), the production of glutamine, citrulline, valine, isoleucine, ornithine, lysine and histidine were all enhanced by the addition of NaCl.”
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