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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Substitution by site-directed mutagenesis of either histidine in motif I by serine , which is not a ligand for metals, results in complete loss of catalytic activity and loss of sensitivity to divalent metal cation activation.”
Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A.“ Ser and Tyr residues on the hinge region make several significant interactions with l-histidine and histidyl moieties.”
Molecular insight in the purification of immunoglobulin by pseudobiospecific ligand l-histidine and histidyl moieties in histidine ligand affinity chromatography (HLAC) by molecular docking.“A synergistic effect involving the two side chains of Ser and His is presumed to be the critical factor for the selectivity of this specific peptide formation.”
Selective Formation of Ser-His Dipeptide via Phosphorus Activation“Biochemical assays and three co‐crystal structures of wild‐type and mutant Csy4/RNA complexes reveal a substrate positioning and cleavage mechanism in which a histidine deprotonates the ribosyl 2′‐hydroxyl pinned in place by a serine , leading to nucleophilic attack on the scissile phosphate.”
“The results suggest that the enzyme may be similar in structure to other cholinesterases, and that both histidine and serine may be involve...”
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