Possible Interaction: Histidine and Pyrilamine

“This effect of l-histidine on behavior was completely abolished by simultaneous administration of pyrilamine or ketotifen (brain-penetrating histamine H(1) receptor antagonists; 10mg/kg each, i.p.),”

“The histamine H1 receptor antagonist pyrilamine (1 µg/site) abolished the ameliorative effects of histidine on working memory deficits, whereas both pyrilamine and the H2 receptor antagonist cimetidine (0.5 µg/site) abolished the effect of histidine on reference memory.”

“The reduction in the late VEP components induced by pyrilamine and diphenhydramine was significantly antagonised by pre-treatment of histidine (200 and 500 mg/kg), but not by physostigmine even at a dose of 0.01 mg/kg.”

“The ameliorating effect of histidine was antagonized by pyrilamine (2-5 mg/kg), a H1-antagonist, but not by zolantidine, a H2-antagonist.”

“Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine , diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine.”

“The effect of pyrilamine was more potently antagonized by histidine and less potently antagonized by physostigmine as compared to diphenhydramine, promethazine and cyproheptadine.”

“The increase in rCBF in the hippocampus induced by L-histidine was antagonized by both H1 and H2 antagonists (diphenhydramine, pyrilamine and zolantidine).”

“1 The contractile action of the dipeptide carnosine β‐alanyl‐l‐histidine ), active as a Zn·carnosine complex (Zn·Carn), was investigated in isolated rings of rabbit saphenous vein (RSV) and was found to be antagonized by the H1 antagonist mepyramine.”

“Moreover, the ameliorating effect of histidine was antagonized by a histamine H1-receptor antagonist, pyrilamine , but not by zolantidine, a histamine H2-receptor antagonist.”

“Moreover, the ameliorating effect of histidine was antagonized by a histamine H1 receptor antagonist, pyrilamine.”