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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Histidine
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ NO binds to the ferrous (Fe(2+)) heme at histidine 105 of the β1 subunit and leads to an increase in sGC activity and cGMP production of at least 200-fold.”
sGC-cGMP signaling: target for anticancer therapy.“In particular, coordination of imidazoles like histidine (His ) increases the radical character on NO and, in this way, could help activate the bound NO for catalysis.”
“Among EleAA, Lys, Trp, His , and Arg (4AA) markedly decreased nitric oxide production and inhibited nuclear factor-κB (NF-κB) activation.”
Elental® amino acid component has protective effects on primary cultured hepatocytes and a rat model of acute liver injury.“Removal of 21 residues from the C-terminus yields a protein with dramatically increased proximal histidine release rates upon NO binding.”
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