Possible Interaction: Histidine and Methionine

“As for previously characterized histone SET domain proteins, the methionine substitution substantially (76-fold) increased binding affinity for SETD3 and inhibited SETD3 activity on histidine.”

“It is suggested that … inhibitory effect of methionine on intestinal absorption and … membrane transport of histidine can explain previously published effects of methionine on the oxidation of the imidazole-2 carbon atom of L-histidine and that a direct effect of methionine on histidine metabolism need not be invoked.”

“The AA_Rev formulation also indicated that His might be a co-limiting AA with Met in dairy rations balanced with ingredients usually included in Canadian dairy rations.”

“We conclude that HIS supplementation increases ammonia production, alanine and glutamine synthesis in muscles, affects turnover of proteins and HIS-containing peptides, and increases requirements for glycine and methionine.”

“Parenteral administration of methionine greatly increased hepatic levels of AdoMet and increased histidine oxidation in normal and N2O treated rats.”

“The results suggest that dietary methionine supplementation enhances the in vivo catabolism of histidine by stimulating one-carbon metabolism.”

“Addition of methionine increases histidine oxidation to approx.”

“The feeding of methionine to the thyroidectomized animal further increases histidine oxidation to 65%.”

“Infusion of methionine , tyrosine, phenylalanine, histidine and tryptophan (designated group 1) resulted in significant increases in the uptakes of tyrosine, phenylalanine and histidine.”

“Added methionine also promotes glucose formation from histidine.”

“The probable mechanism operating to produce this effect is suggested by the work ofWiseman (1955) who showed … mono-amino-mono-carboxylic acids compete for the concentrating mechanism of the hamster small intestine and that methionine completely inhibits the active … glycine, L-proline and L-histidine when present … equimolecular amounts.”