Possible Interaction: Histidine and Lysine

“Alteration of lysine 220 to alanine, histidine , or arginine significantly impaired enzyme function.”

“Uptake of L-lysine in the absence of Na+ was inhibited completely by L-arginine, L-histidine , and L-homoarginine.”

“ Histidine and lysine fluctuated.”

“Apparently, in aspartate aminotransferase, histidine can to some extent substitute for the active-site lysine residue.”

“… lysine 110 … histidine , to provide a pH-sensitive positive charge at this position in the neutral pH range, exhibited only a moderate 25-fold increase in … at pH 8.5 the Km for NADH rose to 238 microM with a decrease of 45% over unmodified enzyme in the kcat.”

“Sensitized photoinactivation of glyoxalated enzyme together with relevant results suggest that the lysine residue provides cationic environment to the hydrophobic active site, and thereby, affects the reactivity of the active site histidine in the dehydrogenase reaction.”

“With these additions of lysine and threonine, there were no responses to additions of tryptophan, methionine or isoleucine, or to further additions of lysine or threonine, but addition of histidine significantly reduced N excretion.”

“1 mM lysine inhibited the uptake of 1 mM alanine, leucine, methionine, phenylalanine, threonine and histidine but not 1 mM valine, isoleucine, tryptophan and proline by epithelial cells isolated from rat intestine.”

“Infusion of arginine, lysine or ornithine into the young cockerel inhibited the renal reabsorption of histidine but did not generally affect the renal reabsorption of neutral and anionic amino acids markedly.”

“Flanking a histidine residue with a lysine or a histidine in positions (i, i + 3), (i, i + 4) or (i, i - 4) resulted in pKa depressions of approximately 0.5 pKa units per residue and additivity was observed.”